Major Research Project on X-Ray Crystallographic Studies of Benzimidazole Derivatives

Major Research Project on X-Ray Crystallographic Studies of Benzimidazole Derivatives

Dr S G Bubbly

Associate Professor, Department of Physics

CHRIST (Deemed to be University), Bangalore – 560029

 

and

 

Co-Investigator

Dr S B Gudennavar

Associate Professor, Department of Physics

CHRIST (Deemed to be University), Bangalore – 560029

 

Abstract:

 

Benzimidazoles are well known heterocyclic compounds which have a major pharmacological role in medicinal chemistry and drug discovery. They are found in many natural compounds and many of their derivatives are being marketed as drugs due to their privileged structure which makes them interact easily with biopolymers of the living system. Researchers have been attracted towards the design of potent benzimidazole derivatives having diverse biological activities and less toxicity. The present research work focuses on the spectroscopic characterization, crystal structure studies, antimicrobial activities and fluorescence studies of eight benzimidazole derivatives. The research work carried out in this project is reported in seven chapters. The first chapter introduces the importance of the work carried out. The structural characterization of three 6-alkyl-5,6-dihydrobenzimidazoquinazoline derivatives (I, II and III) by elemental analysis, IR, UV-Vis, 1H NMR, 13C NMR and single crystal X-ray structure analysis are presented in chapter 2. The results of the antimicrobial activity studies against four bacterial strains Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Pseudomonas and the fungal strains Candida albicans and Cryptococcus neoformans are also included. Details regarding structural characterization of two substituted 6-phenyl-5, 6-dihydrobenzimidazoquinazolines, (IV and V) are given in chapter 3. Chapter 4 deals with the spectroscopic characterization, single crystal X-ray diffraction studies and antimicrobial activity studies of two 2-phenyl-1H-benzimidazole derivatives (VI and VII).In chapter 5, spectroscopic characterization and single crystal X-ray diffraction studies of a hybrid molecule (VIII) of benzimidazole ring and salicylaldehyde conjugated through an azomethine linkage, is presented. The effect of solvents of varying polarity on the absorption and fluorescence emission of this Schiff base compound (VIII) is reported in chapter 6. Fluorescence quenching studies of VIII by aniline in 1, 4-dioxane and n-butanol are also presented in this chapter. The summary and conclusions of the present investigation are given in chapter 7.

 

 

Year of Publication: June 2014

ISBN  978-93-82305-68-2

Major Research Project: Vol 13

Pages  xii, 54

Price: available on request

Funded by Centre for Research-Projects-CHRIST (Deemed to be University)

Published by Centre for Publications, CHRIST (Deemed to be University)